I have a set of Moto TalkAbouts - picked Moto because so far I have been able to match up many other folks out there without a problem and use the extra "quiet" filter to make it more clear. Sadly as mentioned they are WAY too quiet compared to a CB.
We just for anything from campsite, hiking (very limited due to mountains), event organization (weddings, volunteer work, traffic people/car crowd control), snowboarding (a life saver here since I have many friends who get lost) and well being lazy to talk to each other on msn / walk upstairs downstairs in the house so the FRS is quite handy
One big advantage over the CB is battery life ... at least on my Moto a fresh charge and leaving it on 24/7 will last about 3-4 days with moderate use (ie setting camping with hiking).